Optimizing NTRK gene fusion detection
NTRK gene fusions are an important class of oncogenes which occur in a wide range of adult and pediatric tumor types.1 Several methods exist to detect genomic alterations. However, features unique to NTRK gene fusions must be considered during testing—making NTRK gene fusion detection an important challenge for pathologists.1,2
Optimizing testing for genomic alterations is the critical first step to identify NTRK gene fusions
This website provides information to help pathologists optimize their NTRK gene fusion testing process.
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DNA, deoxyribonucleic acid; FISH, fluorescence in situ hybridization; IHC, immunohistochemistry; NGS, next-generation sequencing; NTRK, neurotrophic tyrosine receptor kinase; RNA, ribonucleic acid; RT-PCR, reverse-transcription polymerase chain reaction.